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PROTO-ONCOGENE PROTEINS C-AKT
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-akt
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-akt
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-akt
Synonyms
English
:
akt Proto-Oncogene Protein
c-akt Protein
Tree Number:
D08.811.913.696.620.682.700.755
D12.776.476.565
D12.776.624.664.700.168
Definition
English
:
A protein-serine-threonine kinase that is activated by
PHOSPHORYLATION
in response to
GROWTH
FACTORS or
INSULIN
. It plays a major
role
in cell
metabolism
,
growth
, and
survival
as a core component of
SIGNAL TRANSDUCTION
. Three isoforms have been described in mammalian
cells.
History Note
English
:
2006(1987)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50724
Unique Identifier:
D051057
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS